Shrestha G, Githumbi R, Oslanski B, Venkova D, Lachman N, Montgomery B, Jarand J, Bjornson CL, Parkins M, Skolnik K, Fairservice L. A Phase IIa Open Label Study to Evaluate the Safety, Tolerability and Efficacy of S-1226 Administered by Nebulization in Subjects with Cystic Fibrosis Lung Disease. medRxiv. 2021. Read Publication>

Wierstra BT, Green FH, Dennis J, Waechter JE. Treatment of Acute Asthma in the ICU with Liquid Perfluorocarbon & CO2 Gas Combination.  Am J Respir Crit Care Med 2018;197:A5269 Read Publication>

Swystun V, Green FHY, Dennis JH, Rampakakis E, Lalli G, Fadayomi M, Chiu A, Shrestha G, El Shahat SG, Nelson DE, El Mays TY, Pieron CA, Leigh R.  A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma. Trials. 2018;19(1):321. Read Publication>

Al-Saiedy M, Pratt R, Lai P, Kerek E, Joice H, Prenner E, Green F, Ling C, Veldhuizen R, Ghandorah S, Amrein M. Dysfunction of pulmonary surfactant mediated by phospholipid oxidation is cholesterol-dependent. 2018, Biochimica et Biophysica Acta, 1862(4) 1040-1049. Read Publication>

Al-Saiedy M, Gunasekara L, Green F, Pratt R, Chiu A, Yang A, Dennis JH, Pieron C, Bjornson C, Winston B, Amrein M. Surfactant Dysfunction in ARDS and Bronchiolitis is Repaired with Cyclodextrins. 2018, Military Medicine 183, 3/4: 207-215. Read Publication>

Gunasekara L, Al-Saiedy M,  Green F, Pratt R, Bjornson C, Yang A, Schoel WM, Mitchell I, Brindle M, Montgomery M, Keys E, Dennis J, Shrestha G, Amrein M. Pulmonary surfactant dysfunction in pediatric cystic fibrosis: Mechanisms and reversal with a lipid-sequestering drug. 2017, J Cystic Fibr. 16 (5) 565-572. Read Publication>

Al-Saiedy M, Tarokh A, Nelson S, Hossini K, Green F, Ling CC, Prenner EJ, Amrein M.  The role of multilayers in preventing the premature buckling of the pulmonary surfactant. 2017, Biochim Biophys Acta 1859 (8):1372-1380. Read Publication>

Boser SR, Mauad T, Bergamo de Araujo-Paulino B, Mitchell I, Shrestha G, Chiu A, Butt J, Kelly MM, Caldini E, James A, Green FHY. Myofibroblasts are increased in the lung parenchyma in asthma. 2017 Plos ONE, 7;12(8):e0182378. doi: 10.1371/journal.pone.0182378. eCollection 2017. Read Publication>

Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park J, Beckerie MC, Pare PD, Fredberg JJ, Smith MA. The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. 2017, PLoS ONE, 12(3): e0171728. doi:10.1371/journal.pone.0171728. Read Publication>

Green FHY, Leigh R, Fadayomi M, Lalli G, Chiu A, Shrestha G, ElShahat SG, Nelson DE, El Mays TY, Pieron CA, Dennis JH. A phase I, placebo-controlled, randomized, double blind, single ascending dose ranging study to evaluate the safety and tolerability of novel biophysical bronchodilator (S-1226) administered by nebulization in normal healthy volunteers. Trials, 2016;17: 361.
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Dennis JH. Asthma rescue with carbonated perflubron: A novel biophysical approach. Respir Drug Deliv, 2016;1: 23-36.
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Green FHY, Leigh R, Swystun V, Shrestha G, Galal S, Fadayomi M, Chiu A, Lalli G, Pieron C, El-Mays T, Nelson DE, Dennis J. A novel and safe inhaled asthma drug: A phase I/II randomized placebo controlled trial. American Thoracic Society International Conference. 2016;193: A6488.
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Dennis J, Clark A, McAffer I, Dalberg S, Green F. First in class, respiratory drug gas & drug vapor delivered in a revolutionary new portable device. European Respiratory Journal. 2015;46: PA4035.
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Dennis J, Leigh R, El Mays T, Green F. Biophysical bronchodilator: A new class of respiratory drug. European Respiratory Journal. 2015;46: PA3609.
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Green F, Leigh R, Shrestha G, Galal S, Chiu A, Fadayomi M, Pieron C, El Mays T, Nelson DE, Al-Saiedy MR, Swystun V, Lewis G, Dennis J. Development of a new bronchodilator to enable better treatment of asthma, COPD, and CF. American Thoracic Society International Conference. 2015;191: A5788.
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Al-Saiedy MR, Nelson DE, Amrein M, Leigh R, Green F. The Role of an Artificial Surfactant in Mucous Plug Clearance In Vitro. American Thoracic Society International Conference. 2015;191: A5997. Read Publication>

Al-Saiedy MR, Pratt R, Green F, Amrein M The Role of Free Radical Attack on Pulmonary Surfactant Dysfunction in Acute Lung Injury and Acute Respiratory Stress Syndrome at Physiological Cholesterol Levels. American Thoracic Society International Conference. 2015;191: A4367 Read Publication>

Al-Saiedy MR, Nelson SL, Tarokh A, Green FHY, Amrien MW. Examining the Collapse-Mechanism of the Pulmonary Surfactant. American Thoracic Society International Conference. 2015;191: A5758. Read Publication>

Elliot JG, Jones RL, Abramson MJ, Green FH, Mauad T, McKay KO, Bai TR, James AL. Distribution of airway smooth muscle remoddeling in asthma: relation to airway inflammation. 2015 Respirology 20 (1): 66-72. Read Publication>

Dennis J, Leigh R, Shrestha G, Galal S, Fadayomi M, Al-Saiedy M, Chiu A, Pieron C, El Mays T, Nelson D, Swystun V, Lewis G, Green F. A new inhaled asthma drug. Drug Delivery to the Lungs Conference (DDL25), Edinburgh, Scotland, December 11-13, 2014.
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El Mays TY, Choudhury P, Leigh R, Koumoundouros E, Van der Velden J, Shrestha G, Pieron CA, Dennis JH, Green F, Snibson KJ.  Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthmaRespir Res, 2014,15: 98.
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Al-Saiedy M, Nelson E, El-Mays T, Amrein M, Green F. Perflubron enhances mucin plug clearance in vitro in the presence of natural surfactant  2013 ERJ 42: 686. Read Publication>

El Mays T, Choudhury P, Leigh R, Dennis JH, Koumoundouros E, Snibson D, Green F. Investigations of mechanisms of carbon dioxide-induced bronchial smooth muscle relaxation. American Thoracic Society International Conference. 2012;185: A2848.
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Dennis J, Pieron C, Nelson D , Benjamin J, Tucker J, Green F, El Mays T, Leigh R.  A novel gravimetric trace residue method to characterize nebulized PFOB. 7th Symposium on Medical Applications of Perfluorocarbons and Liquid Ventilation. Paris, France, 2012.

Choudhury P, El Mays T, Snibson K, Wilson R, Leigh R, Dennis J, Nelson DE, Green F. Investigations of Mechanisms of Carbon Dioxide-Induced Bronchial Smooth Muscle Relaxation. 2012, Am J of Resp and Crit Care Med 185: A2848. Read Publication>

El Mays T, Dennis JH. Treating acute asthma with perfluorocarbons and carbon dioxide. 7th Symposium on Medical Applications of Perfluorocarbons and Liquid Ventilation. Paris, France, 2012.

El Mays T, Choudhury P, Leigh R, Dennis JH, Koumoundouros E, Snibson D, Green F. A potential life-saving treatment of severe acute asthma. Chest. 2011;140: 239A
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El Mays T, Saiffeddine M, Choudhury P, Hollenberg MD, Green FHY. Carbon dioxide enhances substance P-induced epithelium-dependent bronchial smooth muscle relaxation in Sprague-Dawley rats. Can J Physiol. Pharmacol. 2011, 89:513-520 Read Publication>

Dennis JH, Tucker J, Leigh R, El Mays R, Green, F. New formulations for opening airways in acute asthma. Journal of Aerosol Medicine. 2011,24(3): A15.
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